Therapeutic Considerations for Docetaxel and Paclitaxel in Metastatic Breast Cancer

Breast cancer is the main source of death among women. Currently, 77% of women diagnosed with breast cancer are age 50 and older; however, it is projected that approximately 66% of the new cases diagnosed will occur in women younger than 65. Several clinical trials have assessed the wellbeing and adequacy of taxanes along with their tolerability in patients with metastatic cancer (MBC) The overview of these Paclitaxel and Docetaxel, the mechanism of action, pharmacokinetics and pharmacodynamics, dose and administration, adverse effects, clinical potency, and sufferable profiles combination therapies, the pathological complete response of these taxanes are included. The different novel formulations of taxanes are formulated from nanoparticles, polyglutamate, liposomes to improve the wellbeing and adequacy taxanes to reduce their toxicities. Single-agent research located with docetaxel and paclitaxel in metastatic breast most cancers show clinically huge antitumor motion even in the advanced stage, heavily pretreated, safe, as properly as in refractory diseases. This action is likewise clear with taxane-based combination regimens. Serious hematologic and nonhematologic toxicities are incompatible, with different toxicities noted dependent on the portion and weekly regimen selected.  Weekly docetaxel and paclitaxel regimens speak to important helpful treatment options for women suffering from metastatic breast cancer and have entered assessment as a major aspect of adjuvant treatment for this disease Toxicity associated with taxanes chemotherapy are based totally on the dose schedules and weekly regimen selected and the most frequent toxicities related with these marketers include myalgia, peripheral neuropathy, neutropenia, etc Docetaxel retains in tumor cells for longer duration when compared to paclitaxel because of its slow efflux and large amounts of uptake into the cell which explains its more benefits when compared to paclitaxel. Clinical studies conducted so far suggested a more benefit to risk ratio for docetaxel when compared to paclitaxel. This article reviews mainly different actions exhibited by taxanes in the therapy of metastatic breast cancer and others on stages of cancer along with the toxicities associated with these agents. &nbsp

Isolation and characterization of a novel agarolytic bacterium vibrio SP.B4-6A from coral reef ecosystem off Tutiocorin

Isolation and characterization of a novel agarolytic bacterium vibrio SP.B4-6A from coral reef ecosystem off Tutiocori

Characterisation of a carotenoid producing extremely halophilic archaeon Halorubrum sodomense MS5.1 isolated from a solar saltern in Tamil Nadu, South India.

A carotenoid producing extremely halophilic archaeon designated MS5.1 was isolated out of brine samples from a crystalliser pond of a marine solar saltern in Kanyakumari District, Tamil Nadu, South India. The red pigmented, long rod shaped haloarchaeon was found to be able to grow at temperature range of 20-40°C, salt concentration of 10-35% and pH range of 6 to 9 with optimum conditions for growth being 28°C; 30% salt and pH 7

Isolation and characterization of a halophilic archaeon Halorubrum sodomense from Manaikudi salt pans, Tamil Nadu, South India

Archaea are mostly unexplored and distinct class of microorganism with unique features and are commonly encountered in extreme environments They are phylogenetically more similar to eukarya than bacteria. Achaeal membrane lacks peptidoglycan but have different membrane lipid bonding Archaeal lipid lacks the fatty acid found in bacteria and eukaryotes and instead have side chains composed of repeating units of isoprene. They are key players of ocean biogeochemical cycles and potential source of novel natural products including chemicals and biomolecules. The present study attempted isolation and characterization of a halophilic archaeon from a solar saltern situated at Manaikkudi Village in Nagercoil District, Tamil Nad

Biodegradation of the pyrethroid pesticide Cyflutrin by the halophilic Bacterium Photobacterium Ganghwense isolated from Coral Reef Ecosystem

Biodegradation of the pyrethroid pesticide Cyflutrin by the halophilic Bacterium Photobacterium Ganghwense isolated from Coral Reef Ecosyste

The Influence Of Maternal Infections On Congenital Heart Defect

ABSTRACT Congenital heart defects (CHDs) contribute significantly to heightened infant mortality rates. This review explores the intricate link between maternal infections and CHDs, emphasizing diverse factors influencing fetal development, such as bacterial, fungal, protozoan and viral agents. These infections pose reproductive health risks, potentially leading to complications like prematurity, stillbirth and heart defect to the fetus. The TORCH acronym (Toxoplasma, Other infections, Rubella, Cytomegalovirus, Herpes simplex) identifies infectious teratogens related to congenital issues, emphasizing vertical transmission through the placenta or ascending from the vagina. Rubella and Cytomegalovirus play a significant role in heart defects, particularly when maternal infections amplify CHD risk during pregnancy. Specific scrutiny is placed on Rubella and Cytomegalovirus for their impact on pregnancy outcomes and potential links to congenital heart defects, with preventive strategies discussed, including vaccination and antiviral therapy. The timing and severity of these infections are pivotal in determining their impact on fetal heart development. Environmental exposures and maternal nutrition are critical factors influencing fetal development. Maternal undernutrition in low- and middle-income countries associates with adverse pregnancy outcomes, including congenital heart defects. Emphasizing the importance of maintaining a nutritious maternal diet, rich in essential nutrients, is crucial for improved fetal health and successful pregnancy outcomes. This review offers insights into preventive measures and underscores the need for continued research to enhance prenatal care strategies

Biodegradation of the pyrethroid pesticide cyfluthrin by the halophilic bacterium Photobacterium ganghwense isolated from coral reef ecosystem

A halophilic bacterial strain T14 isolated from the mucus of coral Acropora formosa was found to be highly effective in degrading the pyrethroid pesticide, cyfluthrin. T14 was identified as Photobacterium ganghwense (GenBank Accession No. MT360254) based on phenotypic and biochemical characteristics as well as by 16S rRNA gene sequence analysis. The pyrethroid degrading efficiency of P. ganghwense T14 strain was examined under different culture conditions. It was observed that P. ganghwense T14 was able to utilise cyfluthrin as a sole carbon source and was found to grow on mineral medium with pesticide concentrations ranging from 10 to 100 mg l-1

A stochastic connectionist approach for global optimization with application to pattern clustering

10.1109/3477.826943IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics30110-24ITSC